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Anti-5 Lipoxygenase/5-LO Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R & H,M,R |
| Applications: | WB & IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: |
5 Lipoxygenase rabbit polyclonal |
| Gene Name: | Arachidonate 5-lipoxygenase |
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Synonyms: |
5-LO, 5-lipoxygenase, Alox5, 5-LOX, 5LPG, LOG5, Arachidonic acid 5 lipoxygenase, Leukotriene A4 synthase |
| Immunogen: |
Recombinant protein corresponding to Mouse 5 Lipoxygenase |
| Isotype: | IgG |
| Purity: | Affinity purification |
| Subcellular location: |
Cytoplasm, Nucleus |
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Predicted MW. |
78 kDa |
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Observed MW. |
78 kDa |
| Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 800 | thymus, brain |
IHC | Human, Mouse, Rat | 1: 2000-1: 4000 | prostate cancer, breast cancer, stomach cancer, lung, bone, colon, small intestine |
IF | Human, Mouse, Rat | 1: 2000-1: 4000 | lung, colon, stomach |
Background
ALOX5(arachidonate 5-lipoxygenase) is also named as LOG5, 5-LO and belongs to the lipoxygenase family. It catalyzes the first step in leukotriene biosynthesis, and plays a role in inflammatory processes. It is a 78 kDa iron-containing enzyme that translocates from the cytosol to associate with FLAP, and converts arachidonate in two steps into the unstable intermediate LTA4. It is essential for cysteinyl-leukotriene (cys-LT) production, critical mediators in asthma.
Images
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Western blot analysis of ALOX5 (GB111330) at dilution of 1: 500 |
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Immunohistochemistry analysis of paraffin-embedded human prostate cancer using ALOX5 (GB111330) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded human breast cancer using ALOX5 (GB111330) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded human stomach cancer using ALOX5 (GB111330) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded human lung using ALOX5 (GB111330) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded mouse lung using ALOX5 (GB111330) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded rat lung using ALOX5 (GB111330) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded mouse bone using ALOX5 (GB111330) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded rat bone using ALOX5 (GB111330) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded rat colon using ALOX5 (GB111330) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded rat small intestine using ALOX5 (GB111330) at dilution of 1: 2000 |
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Immunofluorescent analysis of paraformaldehyde-fixed human lung using ALOX5 (GB111330) at dilution of 1: 2000 |
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Immunofluorescent analysis of paraformaldehyde-fixed mouse lung using ALOX5 (GB111330) at dilution of 1: 2000 |
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Immunofluorescent analysis of paraformaldehyde-fixed rat colon using ALOX5 (GB111330) at dilution of 1: 2000 |
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Immunofluorescent analysis of paraformaldehyde-fixed rat stomach using ALOX5 (GB111330) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
