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ABflo® 647 Rabbit anti-Human CDA mAb (100 T)
| Reactivity: | Human |
| Applications: | FC (intra) |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal Antibody |
| Conjugation: | ABflo® 647. Ex:648nm. Em:664nm. |
| Gene Name: | cytidine deaminase |
| Gene Symbol: | CDA |
| Synonyms: | CDD |
| Gene ID: | 978 |
| UniProt ID: | P32320 |
| Clone ID: | 9J1K0 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-146 of human CDA(NP_001776.1). |
| Dilution: | FC (intra),5 μl per 10^6 cells in 100 μl volume |
| Purification Method: | Affinity purification |
| Concentration: | 0.01 mg/mL |
| Buffer: | PBS with 0.03% proclin300,0.2% BSA, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-CDA Antibody |
Background
This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.
Images
 | Flow cytometry: 1×10^6 HEL cells (negative control,left) and HeLa cells (right) were intracellularly-stained with ABflo® 647 Rabbit anti-Human CDA mAb (A24687,5 μl/Test,orange line) or ABflo® 647 Rabbit IgG isotype control (A22070,2 μg/mL,blue line). Non-fluorescently stained cells were used as blank control (red line). |
 | Flow cytometry: 1×10^6 HeLa cells were intracellularly-stained with ABflo® 647 Rabbit IgG isotype control (A22070,2 μg/mL,left) or ABflo® 647 Rabbit anti-Human CDA mAb (A24687,5 μl/Test,right). |
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