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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Active breakpoint cluster region-related protein |
Synonyms: | Active BCR related, Active BCR related gene, MDB, abr, Active breakpoint cluster region related protein |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ABR |
Uniprot ID: | Q5SSL4 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 98 kDa / 120 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 300-1: 600 | lung,colon |
Background
Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. Functions as an important negative regulator of neuronal RAC1 activity. Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity.
Images
| Western blot analysis of ABR (GB114844) at dilution of 1: 60 |
| Western blot analysis of ABR (GB114844) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
