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| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Adrenocortical dysplasia protein |
Synonyms: | ACD, PIP1, PTOP, TINT1, TPP1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ACD |
Uniprot ID: | Q5EE38 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 45 kDa / 60 kDa |
Product Usage Information
WB | Human, Mouse | 1: 300-1: 500 | spleen |
Background
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation.
Images
| Western blot analysis of ACD (GB114290) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
