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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ACK1 rabbit polyclonal antibody |
Gene Name: | Activated CDC42 kinase 1 |
Synonyms: | ACK-1, Non-receptor protein tyrosine kinase Ack, Tyrosine kinase non-receptor protein 2, Tnk2, Ack1 |
Immunogen: | Recombinant protein corresponding to Mouse ACK1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cell membrane, Cytoplasm |
Uniprot ID: | O54967 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 1000-1: 4000 | brain |
Background
TNK2, also named as ACK1, belongs to the protein kinase superfamily and Tyr protein kinase family. It is a non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. TNK2 transduces extracellular signals to cytosolic and nuclear effectors. It is a downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. TNK2 confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.
Images
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Immunohistochemistry of paraffin embedded mouse brain using ACK1 (GB111439) at dilution of 1:2000 (200x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
