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Anti-ADAMTS4 Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ADAMTS4 rabbit polyclonal |
| Gene Name: | A disintegrin and metalloproteinase with thrombospondin motifs 4 |
Synonyms: | Adamts4, ADAMTS4, ADAMTS-2, ADAMTS-4, ADMP-1, ADAM metallopeptidase with thrombospondin type 1 motif 4 |
| Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ADAMTS4 |
| Isotype: | IgG |
| Purity: | Affinity purification |
| Subcellular location: | Secreted |
| Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1:500-1:3000 | brain, spinal cord, lung |
IF | Mouse, Rat | 1:250-1:500 | brain, spinal cord, lung |
Background
A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme encoded by the ADAMTS4 gene. ADAMTS4 is the shortest known ADAMTS, lacking the C-terminal domain and is the only non-glycosylated ADAMTS. This protein cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. The protein may play an important role in the destruction of aggrecan in arthritic diseases. It could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease.
Images
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Immunohistochemistry analysis of paraffin-embedded rat prefrontal lobe using ADAMTS4 (GB11807) at dilution of 1: 500 |
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Immunohistochemistry analysis of paraffin-embedded mouse substantia nigra using ADAMTS4 (GB11807) at dilution of 1: 500 |
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Immunohistochemistry analysis of paraffin-embedded mouse cerebellum using ADAMTS4 (GB11807) at dilution of 1: 500 |
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Immunohistochemistry analysis of paraffin-embedded mouse spinal cord using ADAMTS4 (GB11807) at dilution of 1: 3000 |
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Immunohistochemistry analysis of paraffin-embedded rat spinal cord using ADAMTS4 (GB11807) at dilution of 1: 3000 |
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Immunohistochemistry analysis of paraffin-embedded rat lung using ADAMTS4 (GB11807) at dilution of 1: 3000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
