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| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | AIF rabbit polyclonal antibody |
Gene Name: | Apoptosis-inducing factor 1, mitochondrial |
Synonyms: | AIFM1, AIF, CMT2D, CMTX4, COWCK, COXPD6, NADMR, NAMSD, PDCD8, DFNX5, apoptosis inducing factor, mitochondria associated 1, apoptosis inducing factor mitochondria associated 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse AIF |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Mitochondrion intermembrane space, Mitochondrion inner membrane, Cytoplasm, Nucleus |
Uniprot ID: | O95831, Q9Z0X1, Q9JM53 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 2000 | heart, skeletal muscle, spleen, thymus, tonsil |
Background
Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e., caspase-independent fragmentation of chromosomal DNA.
Images
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Immunohistochemistry of paraffin embedded human tonsil using AIF (GB11314) at dilution of 1:800 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse spleen using AIF (GB11314) at dilution of 1:800 (400x lens) |
| Immunohistochemistry of paraffin embedded rat spleen using AIF (GB11314) at dilution of 1:800 (400x lens) |
| Immunohistochemistry of paraffin embedded rat thymus using AIF (GB11314) at dilution of 1:800 (400x lens) |
| Immunofluorescence of paraffin embedded mouse heart using AIF (GB11314) at dilution of 1:1000 (400x lens) |
| Immunofluorescence of paraffin embedded mouse skeletal muscle using AIF (GB11314) at dilution of 1:1000 (400x lens) |
| Immunofluorescence of paraffin embedded mouse skeletal muscle using AIF (GB11314) at dilution of 1:1000 (400x lens) |
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Immunofluorescence of paraffin embedded rat skeletal muscle using AIF (GB11314) at dilution of 1:1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
