Your shopping cart is empty!
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | RAC-gamma serine/threonine-protein kinase |
Synonyms: | AKT3, PKB GAMMA, PKBG, PRKBG, Protein kinase Akt 3, Protein kinase B gamma, RAC gamma, RAC PK gamma, STK 2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse AKT3 |
Uniprot ID: | Q9WUA6 |
Isotype: | lgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 200-1: 600 | liver, kidney, brain |
Background
AKT3 is one of 3 closely related serine/threonine-protein kinases called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
Images
| Immunohistochemistry analysis of paraffin embedded human esophageal cancer using AKT3 (GB115583) at dilution of 1: 200 |
| Immunohistochemistry analysis of paraffin embedded human kidney using AKT3 (GB115583) at dilution of 1: 200 |
| Immunohistochemistry analysis of paraffin embedded mouse liver using AKT3 (GB115583) at dilution of 1: 200 |
| Immunohistochemistry analysis of paraffin embedded mouse liver using AKT3 (GB115583) at dilution of 1: 200 |
| Immunohistochemistry analysis of paraffin embedded rat brain using AKT3 (GB115583) at dilution of 1: 200 |
| Immunohistochemistry analysis of paraffin embedded rat kidney using AKT3 (GB115583) at dilution of 1: 200 |
| Immunohistochemistry analysis of paraffin embedded rat spleen using AKT3 (GB115583) at dilution of 1: 200 |
| Immunohistochemistry analysis of paraffin embedded rat testis using AKT3 (GB115583) at dilution of 1: 200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
