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Anti-ALK-7 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ALK-7 rabbit polyclonal antibody |
Gene Name: | Activin receptor type-1C |
Synonyms: | Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7, Alk7, Acvr1c |
Immunogen: | Recombinant protein corresponding to Mouse ALK-7 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 55 kDa |
Observed MW. | 55 kDa |
Uniprot ID: | Q8K348, P70539 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | kidney, pancreas |
Background
ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.
Images
| Western blot analysis of ALK-7 (GB111950) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
