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Anti-AMACR Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Alpha-methylacyl-CoA racemase |
Synonyms: | 2 methylacyl CoA racemase, alpha methylacyl CoA racemase, AMACR, CBAS4, p504S, RACE |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human AMACR |
Uniprot ID: | Q9UHK6 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Images
Applications | Species | Dilution | Positive tissue |
IHC/IF | Human | 1:600-1:1200 | colon, ovarian cancer, prostatic cancer |
Background
AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR. Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4).
Images
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Immunohistochemistry of paraffin embedded human colon using AMACR (GB111195) at dilution of 1:600 (400x lens) |
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Immunohistochemistry of paraffin embedded human ovarian cancer using AMACR (GB111195) at dilution of 1:1200 (400x lens) |
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Immunohistochemistry of paraffin embedded human prostatic cancer using AMACR (GB111195) at dilution of 1:1200 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
