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Anti-AMPK gamma 1 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | AMPK gamma 1 rabbit polyclonal antibody |
Gene Name: | 5'-AMP-activated protein kinase subunit gamma-1 |
Synonyms: | AMPK gamma1, AMPK subunit gamma-1, AMPKg, Prkag1, Prkaac |
Immunogen: | Recombinant protein corresponding to Mouse AMPK gamma 1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 38 kDa |
Observed MW. | 38 kDa |
Uniprot ID: | O54950, P80385 |
Images
Applications | Species | Dilution | Positive tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | heart, brain, muscle |
Background
AMP/ATP-binding subunit of AMP-activated protein kinase, an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.
Images
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Western blot analysis of AMPK-γ1 (GB111090) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
