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| Reactivity: | M & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Anoctamin-6 |
Synonyms: | ANO6, anoctamin 6, TMEM16F, Transmembrane protein 16F |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ANO6 |
Uniprot ID: | Q6P9J9 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 106 kDa / 95 kDa |
Product Usage Information
WB | Mouse | 1: 500-1: 1000 | liver, kidney |
IHC/IF | Mouse, Rat | 1: 700-1: 2100 | kidney, ileum |
Background
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.
Images
| Western blot analysis of ANO6 (GB115235) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse kidney using ANO6 (GB115235) at dilution of 1: 700 |
| Immunohistochemistry analysis of paraffin embedded rat ileum using ANO6 (GB115235) at dilution of 1: 700 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
