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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | AUH rabbit polyclonal antibody |
Gene Name: | Methylglutaconyl-CoA hydratase, mitochondrial |
Synonyms: | AU-specific RNA-binding enoyl-CoA hydratase, AU-binding enoyl-CoA hydratase, muAUH, Itaconyl-CoA hydratase, Auh |
Immunogen: | Recombinant protein corresponding to Mouse AUH |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 33 kDa |
Observed MW. | 28 kDa |
Uniprot ID: | Q9JLZ3, F1LU71 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | heart, brain, kidney, liver |
Background
The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity.
Images
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Western blot analysis of AUH (GB111521) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
