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| Reactivity: | Human |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | Nuclear receptor subfamily 4 group A member 1 |
| Gene Symbol: | NR4A1 |
| Synonyms: | HMR; N10; TR3; NP10; GFRP1; NAK-1; NGFIB; NUR77; [KD Validated] NUR77 |
| Gene ID: | 3164 |
| UniProt ID: | P22736 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human NUR77 (NP_002126.2) |
| Dilution: | WB 1:1000-1:2000 |
| Purification Method: | Affinity purification |
| Buffer: | PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-NR4A1 monoclonal antibody |
Background
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Images
 | Western blot analysis of lysates from PC-3 cells, using [KD Validated] NUR77 Rabbit mAb (A24016) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Western blot analysis of lysates from wild type(WT) and NUR77 knockdown (KD) HeLa cells, using [KD Validated] NUR77 Rabbit mAb (A24016) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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