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KO-Validated IFNGR1 Rabbit mAb (20 μl)
| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | interferon gamma receptor 1 |
| Gene Symbol: | IFNGR1 |
| Synonyms: | CD119; IFNGR; IMD27A; IMD27B; R1 |
| Gene ID: | 3459 |
| UniProt ID: | P15260 |
| Clone ID: | 2B9Q1 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 270-489 of human IFNGR1 (NP_000407.1). |
| Dilution: | WB 1:1000-1:2000 |
| Purification Method: | Affinity purification |
| Concentration: | 1.09 mg/ml |
| Buffer: | PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-IFNGR1 monoclonal antibody |
Background
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
Images
 | Western blot analysis of various lysates, using [KO Validated] IFNGR1 Rabbit mAb (A11653) at1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 180s. |
 | Western blot analysis of lysates from wild type(WT) and IFNGR1 knockout (KO) 293T cells, using [KO Validated] IFNGR1 Rabbit mAb (A11653) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Enhanced Kit (RM00021). Exposure time: 180s. |
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