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| Product Category: | Human Adenovirus Type5 (dE1/E3) expressing Chromodomain Helicase DNA Binding Protein 5 (CHD5). |
| Description: | Chromodomain Helicase DNA Binding Protein 5, pre-made adenovirus, ready to ship and ready to use format. |
| Gene: | Chromodomain Helicase DNA Binding Protein 5 |
| NCBI Acc. #: | NM_015557 |
| Gene ID: | 26038 |
| GI Number: | 24308088 |
| Fusion Tag: | No |
| Promoter: | CMV |
| Titer: | 1x1011~1x1012 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | CHD5 (Chromodomain helicase DNA binding protein 5) is a member of the SNF2/RAD54 helicase family of chromatin remodeling and DNA-binding proteins (CDH proteins). Heavily expressed in both fetal and adult brain, CHD5 plays a role in nervous system development and acts as a tumor suppressor via the Arf/p53 pathway. CHD5, along with other chromo-domain proteins, forms remodeling complexes, such as NuRD, that promote normal neuroblast maturation and are thought to prevent overexpression of neuronal cells. Errors in these chromatin remodeling complexes can leave the cell in a perpetual state of growth, preventing differentiation and leading to tumor formation. Due to the importance of the CHD proteins in proper brain development, deletions in the gene encoding CHD5 are commonly found in neuroblastomas, suggesting that CHD5 deficiency may lead to malignant cell transformation and metastasis. |
| Documents: | Please contact us to request the manual |
