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| Product Category: | Human Adenovirus Type5 (dE1/E3) expressing Claudin 19 under CMV promoter. |
| Description: | Claudin 19, pre-made adenovirus, ready to ship and ready to use format. |
| Gene: | Claudin 19 |
| NCBI Acc. #: | BC030524.1 |
| Gene ID: | 9634 |
| GI Number: | 149641 |
| Fusion Tag: | No; Co-expression with GFP |
| Promoter: | CMV |
| Titer: | 1×1010~1×1011 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | The product of the Claudin 19 gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. |
| Storage: | -80°C |
| Documents: | Please contact us to request the manual |