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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing DUSP1.
Description:
Human Adenovirus Type5 (dE1/E3) expressing Dual Specificity Phosphatase 1 (DUSP1) under CMV promoter.
Gene Name:
Dual Specificity Phosphatase 1
ACCN:
BC022463
Gene ID:
1843
GI Number:
18490272
Fusion Tag:
C-terminus V5 epitope
Promoter:
CMV
Titer:
1E+10~1E+11 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
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