Your shopping cart is empty!
Product Category:
Human Adenovirus Type5 (dE1/E3) expressing IRS1 gene under CMV promoter.
Description:
Insulin Receptor Substrate 1, pre-made adenovirus, ready to ship and ready to use format.
Gene Name:
Insulin Receptor Substrate 1
ACCN:
BC053895.1
Gene ID:
3667
GI Number:
3667
Fusion Tag:
No
Promoter:
CMV
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
IRS1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor.
Documents:
