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| Product Category: | Human Adenovirus Type5 (dE1/E3) expressing IRS1 gene under CMV promoter. |
| Description: | Insulin Receptor Substrate 1, pre-made adenovirus, ready to ship and ready to use format. |
| Gene: | Insulin Receptor Substrate 1 |
| NCBI Acc. #: | BC053895.1 |
| Gene ID: | 3667 |
| GI Number: | 3667 |
| Fusion Tag: | No |
| Promoter: | CMV |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | IRS1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor. |
| Documents: | Please contact us to request the manual |
