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| Product Category: | Human Adenovirus Type5 (dE1/E3) expressing Leukocyte Cell Derived Chemotaxin 1 (LECT1) under a CMV promoter. |
| Description: | Leukocyte Cell Derived Chemotaxin 1, pre-packaged adenovirus, ready to ship and ready to use format. |
| Gene: | Leukocyte Cell Derived Chemotaxin 1 |
| NCBI Acc. #: | NM_007015 |
| Gene ID: | 11061 |
| GI Number: | 5901931 |
| Fusion Tag: | C-terminus V5 epitope tag |
| Promoter: | CMV |
| Titer: | 1×1010~1×1011 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | The LECT1 gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Storage: | -80°C |
| Documents: | Please contact us to request the manual |