Your shopping cart is empty!
Product Category:
Human Adenovirus Type5 (dE1/E3) expressing human Lipin 1.
Description:
Pre-made adenovirus for over-expression of human Lipin 1; Ready to ship and ready to use format.
Gene Name:
Lipin 1
ACCN:
BC030537
Gene ID:
23175
GI Number:
20987794
Fusion Tag:
C-terminus V5 tag
Promoter:
CMV
Titer:
1×1010~1×1011 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1A; target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARA. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
Storage:
-80°C
Documents:
