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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing NGFI-A binding protein 2 (EGR1 binding protein 2) under CMV promoter.
Description:
NGFI-A binding protein 2 (EGR1 binding protein 2), pre-made adenovirus, ready to ship and ready to use format.
Gene Name:
NGFI-A binding protein 2 (EGR1 binding protein 2)
ACCN:
BC065931.1
Gene ID:
4665
GI Number:
41946898
Fusion Tag:
V5 epitope tag in C-terminal
Promoter:
CMV
Titer:
1x1010~1x1011 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2 has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3-14.1, a region that is rearranged in several solid tumors, lipomas and liposarcomas.
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