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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing NEUROG1.
Description:
This recombinant human adenovirus type 5 (dE1/E3) expresses human Neurogenin 1 (NEUROG1) under CMV promoter.
Gene Name:
Neurogenin 1
ACCN:
NM_006161
Gene ID:
4762
GI Number:
5453769
Fusion Tag:
C-terminus V5 epitope tag
Promoter:
CMV
Titer:
1x1010~1x1011 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
Neurogenin 1 is a basic helix-loop-helix (bHLH) proteins are transcription factors involved in determining cell type during development. NeuroG1 is a bHLH protein with dual cell-fate specification roles. It functions during neurogenesis, and it has also been shown to inhibit the differentiation of neural stem cells into astrocytes. NeuroG1 promotes neurogenesis by functioning as a transcriptional activator, yet it inhibits astrocyte differentiation by compartmentalizing the CREB-binding protein transcription complex away from astrocyte differentiation genes and by inhibiting STAT transcription factors essential for gliogenesis.
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