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Product Category:
Human Adenovirus Type5 (dE1/E3) expressing Neuronal Guanine Nucleotide Exchange Factor (NGEF).
Description:
Neuronal Guanine Nucleotide Exchange Factor, pre-made adenovirus, ready to ship and ready to use format.
Gene Name:
Neuronal Guanine Nucleotide Exchange Factor
ACCN:
BC031573
Gene ID:
25791
GI Number:
21595071
Fusion Tag:
C-terminus V5 epitope tag
Promoter:
CMV
Titer:
1x1010~1x1011 PFU/ml
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
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