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| Product Category: | Human Adenovirus Type5 (dE1/E3) expressing Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3). |
| Description: | Nuclear Receptor Subfamily 1, Group H, Member 3, pre-made adenovirus, ready to ship and ready to use format. |
| Gene: | Nuclear Receptor Subfamily 1, Group H, Member 3 |
| NCBI Acc. #: | NM_005693 |
| Gene ID: | 10062 |
| GI Number: | 10062 |
| Fusion Tag: | No |
| Promoter: | CMV |
| Titer: | 1x1010~1x1011 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism. |
| Documents: | Please contact us to request the manual |
