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| Product Category: | Human Adenovirus Type5 (dE1/E3) expressing Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1). |
| Description: | Nuclear Receptor Subfamily 4, Group A, Member 1, pre-made adenovirus, ready to ship and ready to use format. |
| Gene: | Nuclear Receptor Subfamily 4, Group A, Member 1 |
| NCBI Acc. #: | BC016147 |
| Gene ID: | 3164 |
| GI Number: | 16359382 |
| Fusion Tag: | No |
| Promoter: | CMV |
| Titer: | 1x1010~1x1011 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | NR4A1 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. NGFI-B-alpha is expressed in brain, adrenal, thyroid, liver, testis, ovary, thymus, muscle, lung and prostate. Its expression is induced in response to various stress stimuli and growth factors. The encoded protein acts as a nuclear transcription factor involved in mediating apoptotic signaling in thymocytes and tumor cells, as well as having a role in signaling in the hypothalamic-pituitary axis. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Three transcript variants encoding two distinct isoforms have been identified for this NR4A1. Variant (3), also known as TRC beta, contains multiple differences compared to variant 1. The resulting isoform b contains a shorter and distinct C-terminus compared to isoform a. RXR has been shown to be a partner for NR4A1. |
| Documents: | Please contact us to request the manual |
