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| Description: | This recombinant human adenovirus type 5 (dE1/E3) expresses human oligodendrocyte lineage transcription factor 2 (OLIG2) with mCherry co-expression under a separate CMV promoter. |
| Gene: | Oligodendrocyte lineage transcription factor 2 |
| NCBI Acc. #: | BC047511 |
| Gene ID: | 10215 |
| GI Number: | 28704079 |
| Promoter: | CMV |
| Titer: | 1x1010~1x1011 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | OLIG2 gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. |
| Documents: | Manual |
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