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| Product Category: | Human Adenovirus Type5 (dE1/E3) expressing Pim-1 Oncogene (PIM1) under a CMV promoter. |
| Description: | Pim-1 Oncogene (PIM1), pre-packaged adenovirus, ready to ship and ready to use format. |
| Gene: | Pim-1 Oncogene |
| NCBI Acc. #: | NM_002648 |
| Gene ID: | 5292 |
| GI Number: | 4505810 |
| Fusion Tag: | C-terminus V5 epitope tag |
| Promoter: | CMV |
| Titer: | 1E+10~1E+11 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | The protein encoded by PIM1 gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810). |
| Documents: | Please contact us to request the manual |
