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| Product Category: | Human Adenovirus Type5 (dE1/E3) expressing RAP1A, also known as KREV-1, KREV1, RAP1 or SMGP21. |
| Description: | RAP1A, Member Of RAS Oncogene Family, pre-made adenovirus, ready to ship and ready to use format. |
| Gene: | RAP1A, Member Of RAS Oncogene Family |
| NCBI Acc. #: | NM_002884 |
| Gene ID: | 5906 |
| GI Number: | 4506412 |
| Fusion Tag: | No |
| Promoter: | CMV |
| Titer: | 1×1011~1×1012 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | Human Rap1 was the first identified ortholog of the yeast telomeric protein scRap1, which shares 3 conserved sequence motifs in common. HRap1 is located at telomeres and affects telomere length by being recruited to telomeres by TRF2 instead of directly binding to the telomere like scRap1. The hRap1 cDNA codes for a protein of 399 amino acids with approximate molecular weight of 47 kDa. The hRap1 protein does not interact with TRF1. TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length(1). TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types. |
| Storage: | -80°C |
| Documents: | Please contact us to request the manual |
