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| Product Category: | Adenovirus Type5 (dE1/E3) expressing human Ret Proto-oncogene (RET) under a CMV promoter with V5 eiptope tag fusion at C-terminal. |
| Description: | Ret Proto-oncogene (multiple Endocrine Neoplasia And Medullary Thyroid Carcinoma 1, Hirschsprung Disease), premade adenovirus, ready to ship and ready to use format. |
| Gene: | Ret Proto-oncogene (multiple Endocrine Neoplasia And Medullary Thyroid Carcinoma 1, Hirschsprung Disease) |
| NCBI Acc. #: | BC004257 |
| Gene ID: | 5979 |
| GI Number: | 13279040 |
| Fusion Tag: | C-terminus V5 epitope tag |
| Promoter: | CMV |
| Titer: | 1E+10~1E+11 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | RET is a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases which are cell-surface molecules that transduce signals for cell growth and differentiation. RET plays a crucial role in neural crest development, can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in the RET gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for the RET gene. Additional transcript variants have been described for RET but their biological validity has not been confirmed. |
| Documents: | Please contact us to request the manual |
