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| Product Category: | Human Adenovirus Type5 (dE1/E3) expressing Survival Of Motor Neuron 1 under CMV promoter. |
| Description: | Survival Of Motor Neuron 1, pre-made adenovirus, ready to ship and ready to use format. |
| Gene: | Survival Of Motor Neuron 1, Telomeric |
| NCBI Acc. #: | BC015308 |
| Gene ID: | 6606 |
| GI Number: | 15929773 |
| Fusion Tag: | No; Co-expression with GFP |
| Promoter: | CMV |
| Titer: | 1×1010~1×1011 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | The SMN1 gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein - survival motor neuron protein. The SMN complex plays a catalyst role in the assemble of small nuclear ribonucleoproteins, the building blocks of the spliceosome. Mutations in the SMN1 gene are known to cause spinal muscular atrophy 1/2. |
| Storage: | -80°C |
| Documents: | Please contact us to request the manual |
