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| Product Category: | Human Adenovirus Type5 (dE1/E3) expressing Sphingosine Kinase 1 under CMV promoter. |
| Description: | Sphingosine Kinase 1, premade adenovirus, ready to ship and ready to use format. |
| Gene: | Sphingosine Kinase 1 |
| NCBI Acc. #: | BC008040 |
| Gene ID: | 8877 |
| GI Number: | 14165485 |
| Fusion Tag: | C-terminus 6xHN tag |
| Promoter: | CMV |
| Titer: | 1E+10~1E+11 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | The protein encoded by SPHK1 gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Documents: | Please contact us to request the manual |
