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| Description: | This recombinant human adenovirus type 5 (dE1/E3) expresses THAP domain containing, apoptosis associated protein 1 (THAP1, also known as DYT6, FLJ10477, MGC33014) under CMV promoter. |
| Gene: | THAP domain containing, apoptosis associated protein 1 |
| NCBI Acc. #: | NM_018105, NP_060575 |
| Gene ID: | 55145 |
| GI Number: | 8922446 |
| Fusion Tag: | V5 tag at C-terminal |
| Promoter: | CMV |
| Titer: | 1×1010~1×1011 PFU/ml |
| Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
| Background: | DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. |
| Storage: | -80°C |
| Documents: | Please contact us to request the manual |
