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Product Category: | Human Adenovirus Type5 (dE1/E3) expressing Tripeptidyl Peptidase I (TPP1). |
Description: | Tripeptidyl Peptidase I, pre-made adenovirus, ready to ship and ready to use format. |
Gene: | Tripeptidyl Peptidase I |
NCBI Acc. #: | BC014863 |
Gene ID: | 1200 |
GI Number: | 15928807 |
Fusion Tag: | No |
Promoter: | CMV |
Titer: | 1x1010~1x1011 PFU/ml |
Storage Buffer: | DMEM with 2.5% BSA, 2.5% glycerol |
Background: | The TPP1 gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. |
Documents: | Please contact us to request the manual |