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Anti-Annexin-7/ANXA7 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Annexin-7 rabbit polyclonal antibody |
Gene Name: | Annexin A7 |
Synonyms: | Annexin VII, Annexin-7, Synexin, Anxa7, Anx7, AnnexinVII, SNX |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Annexin-7 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 50 kDa |
Observed MW. | 50 kDa |
Uniprot ID: | P20073, Q07076, Q6IRJ7 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | heart, lung |
Background
ANXA7 is a member of the annexin family of calcium/phospholipid-binding proteins, and is involved in the process of membrane fusion and exocytosis . Annexin A7 is a GTPase, and both GTPbinding and PKC activity are important in regulating protein function . Membrane binding of annexin A7 is calcium dependent . Two isoforms exist due to alternative splicing. Subcellular localization of annexin A7 has been shown to be in the cytoplasm, vesicular structures, membrane and in adrenal chromaffin granules . Nuclear localization has been shown in the developing mouse central nervous system as well as in adult mouse brain . Annexin A7- deficient mouse studies show that the protein has a role in insulin secretion and calcium signaling as well as cardiac intracellular calcium homeostasis electrical stability . The gene for annexin A7 is a putative tumor suppressor , and alterations in the copy number have been reported in prostate cancer .
Images
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Western blot analysis of Annexin-A7 (GB11950) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
