Your shopping cart is empty!
Reactivity: | Mouse |
Applications: | FCM |
Host Species: | Rat |
Isotype: | Rat IgG2b, κ |
Clonality: | Monoclonal |
Conjugation: | Biotin |
Synonyms: | B7-H1, PD-L1, Programmed cell death ligand 1, B7 homolog 1, B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1 |
Background: | CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production. |
Gene ID: | 60533 |
SwissProt: | Q9EP73 |
Concentration: | 0.5 mg/mL |
Buffer: | PBS with 0.05% Proclin300, 1% BSA |
Storage: | Store at 2~8°C. Do not freeze. |
Documents: | Please contact us to request the manual |