Biotin Anti-Mouse CD274/PD-L1 Antibody (50 μg)

Biotin Anti-Mouse CD274/PD-L1 Antibody (50 μg)

Cat. #: FD1258
Availability: In Stock
$219.00
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Reactivity: Mouse    
Applications: FCM    
Host Species: Rat    
Isotype: Rat IgG2b, κ    
Clonality: Monoclonal    
Conjugation: Biotin    
Synonyms: B7-H1, PD-L1, Programmed cell death ligand 1, B7 homolog 1, B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1
Background: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.
Gene ID: 60533
SwissProt: Q9EP73
Concentration: 0.5 mg/mL    
Buffer: PBS with 0.05% Proclin300, 1% BSA
Storage: Store at 2~8°C. Do not freeze.
Documents: Please contact us to request the manual

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