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Reactivity: | Mouse |
Applications: | FCM |
Host Species: | Rat |
Isotype: | Rat IgG2a, κ |
Clonality: | Monoclonal |
Conjugation: | Biotin |
Synonyms: | T-lymphocyte activation antigen CD86,Cd86,Activation B7-2 antigen,Early T-cell costimulatory molecule 1,ETC-1 |
Background: | CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells. |
Gene ID: | 12524 |
SwissProt: | P42082 |
Concentration: | 0.5 mg/mL |
Buffer: | PBS with 0.05% Proclin300, 1% BSA |
Storage: | Store at 2~8°C. Do not freeze. |
Documents: | Please contact us to request the manual |