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| Reactivity: | Human |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | FOS like 1, AP-1 transcription factor subunit |
| Gene Symbol: | FOSL1 |
| Synonyms: | FRA; FRA1; fra-1; [KD Validated] FOSL1 |
| Gene ID: | 8061 |
| UniProt ID: | P15407 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human FOSL1 (NP_005429.1?). |
| Dilution: | WB 1:1000-1:12000 |
| Purification Method: | Affinity purification |
| Concentration: | 1.32 mg/ml |
| Buffer: | PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-FOSL1 polyclonal antibody |
Background
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene.
Images
 | Western blot analysis of lysates from wild type(WT) and FOSL1 knockdown (KD) U-87MG cells, using [KD Validated] FOSL1 Rabbit pAb (A21988) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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