Your shopping cart is empty!
KD-Validated Proprotein Convertase 9 (PCSK9) Rabbit mAb (20 μl)
| Reactivity: | Human |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | proprotein convertase subtilisin/kexin type 9 |
| Gene Symbol: | PCSK9 |
| Synonyms: | FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3; [KD Validated] Proprotein Convertase 9(PCSK9) |
| Gene ID: | 255738 |
| UniProt ID: | Q8NBP7 |
| Clone ID: | 9L4U5 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 593-692 of human Proprotein Convertase 9(PCSK9) (NP_777596.2). |
| Purification Method: | Affinity purification |
| Concentration: | 1.00 mg/ml |
| Buffer: | PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-PCSK9 monoclonal antibody |
Background
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
Images
 | Western blot analysis of lysates from HepG2 cells, using [KD Validated] Proprotein Convertase 9(PCSK9) Rabbit mAb (A11532) at1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Western blot analysis of lysates from wild type(WT) and Proprotein Convertase 9(PCSK9) knockdown (KD) HeLa cells, using Proprotein Convertase 9(PCSK9) Rabbit mAb (A11532) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
You may also be interested in:
