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| Reactivity: | Human |
| Applications: | WB, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | PDZ binding kinase |
| Gene Symbol: | PBK |
| Synonyms: | SPK; CT84; TOPK; HEL164; Nori-3; PK |
| Gene ID: | 55872 |
| UniProt ID: | Q96KB5 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-322 of human SPK (NP_060962.2). |
| Dilution: | WB 1:1000-1:2000; IHC 1:100-1:1000 |
| Purification Method: | Affinity purification |
| Concentration: | 2.4 mg/mL |
| Buffer: | PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-PBK polyclonal antibody |
Background
This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants.
Images
 | Western blot analysis of lysates from wild type (WT) and SPK knockout (KO) 293T cells, using [KO Validated] SPK Rabbit pAb (A19947) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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