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| Reactivity: | Human |
| Applications: | WB, IHC, IP, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Polyclonal antibody |
| Gene Name: | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 |
| Gene Symbol: | SAMHD1 |
| Synonyms: | DCIP; CHBL2; HDDC1; MOP-5; SBBI88; hSAMHD1; D1 |
| Gene ID: | 25939 |
| UniProt ID: | Q9Y3Z3 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 387-626 of human SAMHD1 (NP_056289.2). |
| Dilution: | WB 1:500-1:2000; IHC 1:50-1:200 |
| Purification Method: | Affinity purification |
| Concentration: | 1.12 mg/ml |
| Buffer: | PBS with 0.02% sodium azide, 50% glycerol ,pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-SAMHD1 polyclonal antibody |
Background
The gene SAMHD1 may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome.
Images
 | Western blot analysis of various lysates using [KO Validated] SAMHD1 Rabbit pAb (A7794) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Western blot analysis of lysates from wild type (WT) and SAMHD1 knockout (KO) HeLa cells, using [KO Validated] SAMHD1 Rabbit pAb (A7794) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min. |
 | Immunohistochemistry analysis of paraffin-embedded Human liver cancer using [KO Validated] SAMHD1 Rabbit pAb (A7794) at dilution of 1:100 (40x lens). Microwave antigen retrieval performed with 0.01M PBS Buffer (pH 7.2) prior to IHC staining. |
 | Immunoprecipitation analysis of 200 μg extracts of HeLa cells using 3 μg SAMHD1 antibody (A7794). Western blot was performed from the immunoprecipitate using SAMHD1 antibody (A7794) at a dilution of 1:1000. |
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