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| Reactivity: | Human, Mouse, Rat |
| Applications: | WB, IHC, IP, ELISA |
| Host Species: | Rabbit |
| Isotype: | IgG |
| Clonality: | Monoclonal antibody |
| Gene Name: | serine/threonine kinase 11 |
| Gene Symbol: | STK11 |
| Synonyms: | PJS; LKB1; hLKB1; B1 |
| Gene ID: | 6794 |
| UniProt ID: | Q15831 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 134-433 of human LKB1. (NP_000446.1). |
| Dilution: | WB 1:3500-1:14000; IHC 1:200-1:2000 |
| Purification Method: | Affinity purification |
| Buffer: | PBS with 0.09% Sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Documents: | Manual-STK11 monoclonal antibody |
Background
The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers.
Images
 | Western blot analysis of lysates from wild type(WT) and LKB1 knockout (KO) 293T cells, using [KO Validated] LKB1 Rabbit mAb (A22636) at 1:7000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry analysis of paraffin-embedded Mouse testis tissue using [KO Validated] LKB1 Rabbit mAb (A22636) at a dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining. |
 | Immunohistochemistry analysis of paraffin-embedded Rat spleen tissue using [KO Validated] LKB1 Rabbit mAb (A22636) at a dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining. |
 | Immunoprecipitation analysis of 300 μg extracts of 293T cells using 3 μg LKB1 antibody (A22636). Western blot was performed from the immunoprecipitate using LKB1 antibody (A22636) at a dilution of 1:7000. |
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