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Anti-14-3-3 Tau Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | 14-3-3 Tau rabbit polyclonal antibody |
Gene Name: | 14-3-3 protein theta |
Synonyms: | 14-3-3 protein tau, Ywhaq |
Immunogen: | Recombinant protein corresponding to Mouse 14-3-3 Tau |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 28 kDa |
Observed MW. | 28 kDa |
Uniprot ID: | P27348, P68254, P68255 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, lung, thymus |
Background
The 14-3-3 family of proteins are important regulatory molecules ubiquitiously expressed in all eukarryotic cells which bind to numerous signaling proteins in various pathways driving critical cellular pathways of apoptosis, differentiation and cell cycle. 14-3-3 theta specifically has also been shown to play an important regulatory role in the TLR2 signaling pathways as a negative regulator of TLR2 ligand Pam3CySk4 induced NF-kB activation. 14-3-3 theta has previously been shown to interact with TLR4 ligand and MyD88 dependent phosphorylated PkC epsilon. 14-3-3 theta in the TLR4 signaling pathway is a positive regulator controlling release of IRF3 indcuded pro-inflammatory cytokines RANTES and IP-10.
Images
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Western blot analysis of 14-3-3 τ (GB111166) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
