Your shopping cart is empty!
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | 2B4 rabbit polyclonal antibody |
Gene Name: | Natural killer cell receptor 2B4 |
Synonyms: | NK cell type I receptor protein 2B4, NKR2B4, Non-MHC restricted killing associated, SLAM family member 4, SLAMF4, Signaling lymphocytic activation molecule 4, CD244, 2b4, Nmrk |
Immunogen: | Recombinant protein corresponding to Mouse 2B4 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 45 kDa |
Observed MW. | 60 kDa |
Uniprot ID: | Q9BZW8, Q07763, Q9JLM2 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | lung, lymph node, spleen, thymus |
Background
CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome.
Images
|
|
Western blot analysis of CD244 (GB111427) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
