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Anti-ADAM15 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ADAM15 rabbit polyclonal antibody |
Gene Name: | Disintegrin and metalloproteinase domain-containing protein 15 |
Synonyms: | ADAM15, MDC15, ADAM metallopeptidase domain 15 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ADAM15 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 93 kDa |
Observed MW. | 93 kDa |
Uniprot ID: | Q13444, O88839, Q9QYV0 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, lung, heart |
Background
ADAM15 belongs to a family of transmembrane proteins that contain disintegrin and metalloprotease domains. Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
Images
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Western blot analysis of ADAM15 (GB11945) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
