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Anti-ADRA1B Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ADRA1B rabbit polyclonal antibody |
Gene Name: | Alpha-1B adrenergic receptor |
Synonyms: | ADRA1, ADRA1B, Alpha-1B adrenoceptor, Alpha-1B adrenoreceptor, ALPHA1BAR |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ADRA1B |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 400-1: 1200 | colon cancer, ovarian cancer, kidney, spleen, testis, brain |
Background
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.
Images
 | Immunohistochemistry analysis of paraffin-embedded human colon cancer using ADRA1B (GB113857) at dilution of 1: 1200 |
 | Immunohistochemistry analysis of paraffin-embedded human ovarian cancerusing ADRA1B (GB113857) at dilution of 1: 1200 |
 | Immunohistochemistry analysis of paraffin-embedded mouse kidney using ADRA1B (GB113857) at dilution of 1: 1200 |
 | Immunohistochemistry analysis of paraffin-embedded mouse spleen using ADRA1B (GB113857) at dilution of 1: 1200 |
 | Immunohistochemistry analysis of paraffin-embedded rat testis using ADRA1B (GB113857) at dilution of 1: 1200 |
 | Immunofluorescent analysis of paraformaldehyde-fixed mouse brain using ADRA1B (GB113857) at dilution of 1: 1200 |
 | Immunofluorescent analysis of paraformaldehyde-fixed rat kidney using ADRA1B (GB113857) at dilution of 1: 1200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
