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Anti-ADRM1/ARM-1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ADRM1 rabbit polyclonal antibody |
Gene Name: | Proteasomal ubiquitin receptor ADRM1 |
Synonyms: | 110 kDa cell membrane glycoprotein, Gp110, Adhesion-regulating molecule 1, ARM-1, Rpn13 homolog, ADRM1, Gp110 |
Immunogen: | Recombinant protein corresponding to Mouse ADRM1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | Q16186, Q9JMB5 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 1000-1: 2000 | brain, breast cancer, colon cancer, esophagus, lung |
Background
ADRM1 is a 407 amino acid protein that localizes to both the nucleus and the cytoplasm and is thought to be involved in protein recruitment and cell adhesion. An integral membrane protein, ADRM1 functions to recruit UCH-L5, a deubiquitinating enzyme, to the 26S proteasome, and once at the proteasome it promotes the activity of UCH-L5. Additionally, ADRM1 is thought to mediate lymphocyte adhesion in endothelial cells and may thus play a role in lymphocyte homing. ADRM1 expression is induced by IFN-g in some cancer cell lines and its expression is upregulated in other metastatic cells, suggesting a role in carcinogenesis.
Images
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Immunohistochemistry of paraffin embedded human breast cancer using ADRM1 (GB111263) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded human colon cancer using ADRM1 (GB111263) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded human esophagus using ADRM1 (GB111263) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse brain using ADRM1 (GB111263) at dilution of 1:1000 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse lung using ADRM1 (GB111263) at dilution of 1:1000 (400x lens) |
| Immunohistochemistry of paraffin embedded rat brain using ADRM1 (GB111263) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat lung using ADRM1 (GB111263) at dilution of 1:1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
