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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | AMF rabbit polyclonal antibody |
Gene Name: | Glucose-6-phosphate isomerase |
Synonyms: | GPI, Autocrine motility factor, AMF, NLK, Neuroleukin, Phosphoglucose isomerase, PGI, PHI, Gpi1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse AMF |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted, Cytoplasm |
Uniprot ID: | P06745, Q6P6V0 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 1500 | brain, spinal cord, spleen |
Background
This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.
Images
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Immunohistochemistry analysis of paraffin-embedded mouse Immune spleen using AMF (GB111160) at dilution of 1: 1000 |
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Immunohistochemistry of paraffin embedded mouse spinal cord using GPI (GB111160) at dilution of 1:500 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse spleen using GPI (GB111160) at dilution of 1:500 (400x lens) |
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Immunohistochemistry of paraffin embedded rat brain using GPI (GB111160) at dilution of 1:500 (400x lens) |
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Immunohistochemistry of paraffin embedded rat spleen using GPI (GB111160) at dilution of 1:500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
