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Anti-APOBEC3C/PBI Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | DNA dC->dU-editing enzyme APOBEC-3C |
Synonyms: | APOBEC1 like, APOBEC1L, APOBEC3, APOBEC3C, ARDC2, ARDC4, ARP5, bK150C2.3, PBI, Phorbolin I |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human APOBEC3C/PBI |
Uniprot ID: | Q9NRW3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 23 kDa / 20 kDa |
Product Usage Information
WB | Human | 1: 500-1: 1000 | HeLa, K562 |
Background
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Images
| Western blot analysis of APOBEC3C (GB114870) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
