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| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ATF6 rabbit polyclonal |
Gene Name: | Cyclic AMP-dependent transcription factor ATF-6 alpha |
Synonyms: | |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ATF6 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1:1000-1:2000 | lung cancer, brain, lung, heart |
IF | Human, Mouse, Rat | 1:1000-1:2000 | lung cancer, brain, lung, heart |
Background
Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N9-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
Images
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Immunohistochemistry analysis of paraffin-embedded human lung cancer using ATF6(GB11297) at dilution of 1:1000 |
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Immunohistochemistry analysis of paraffin-embedded human Endometrial cancer using ATF6(GB11297) at dilution of 1:1000 |
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Immunohistochemistry analysis of paraffin-embedded mouse spinal marrow using ATF6(GB11297) at dilution of 1:1000 |
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Immunohistochemistry analysis of paraffin-embedded mouse heart using ATF6(GB11297) at dilution of 1:1000 |
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Immunohistochemistry analysis of paraffin-embedded rat lung using ATF6(GB11297) at dilution of 1:1000 |
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Immunohistochemistry analysis of paraffin-embedded rat brain using ATF6(GB11297) at dilution of 1:1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
